Modafinil Vs. Flmodafinil; Key Differences And Similarities

You might also be one of those people who struggle with extreme sleepiness during the daytime, and it hinders your work and progress. One can not work appropriately if his brain is not active. You might have tried taking caffeine, tobacco, and other beverages, and nothing is working for you. Here you will find the solution called Central Nervous System stimulants, also termed psychostimulants. They are named modafinil and flmodafinil.

Modafinil comes under the brand name Provigil, helps to treat extreme sleepiness due to sleep disorders. It acts as a weak, selective, and atypical dopamine reuptake inhibitor that activates the release of orexin neuropeptides and histamine, contributing to arousal.

While Flmodafinil is a derivative of Modafinil, the effect of flmodafinil lasts 40% longer due to its higher bioavailability. It works as a neuroprotective agent, antidepressant, anti-aggressive, and dopamine reuptake inhibitor. Its controlled dose gives you a boost in cognition and productivity.

You might wonder how do these medications work to activate your brain? These two compounds, Modafinil, and flmodafinil are from the class of drugs called Eugeroic. Both of them promote wakefulness and are used to treat sleeping conditions. Both of these drugs are listed as controlled substances by the United States Drug Enforcement Administration. These drugs work almost the same with few similarities and differences. Before taking these stimulants you should know that the similarities between modafinil and flmodafinil are:

A Similar Mechanism Of Action

The exact mechanism of action of both of these stimulants is still unknown. Still, we say that modafinil and flmodafinil work on Central Nervous System (CNS) and boost dopamine activity in the brain. They have a meager potential for abuse and dependence, i.e., one can not get addicted to them. They come in the category of safe and controlled substances but are available with a prescription. The purpose of the prescription is to take the measured dose according to the BMI of every person. The regulated dose has the maximum effects with minimum side effects. We can say that both modafinil and flmodafinil are wakefulness-promoting agents and have stimulants-like effects.

Conditions Treated By These Drugs

Narcolepsy, Shift work disorder, Obstructive sleep apnea, Cancer-related fatigue, and Multiple sclerosis-related diseases are seen to be treated by Modafinil and Flmodafinil. Not only physical but mental conditions are also known to be treated by both drugs. Psychiatric disorders like depression, anxiety, ADHD (Attention deficit hyperactivity disorder) can be treated by the controlled dose of modafinil and flmodafinil.  

Safe, Potent And Have long-lasting Effects

As mentioned earlier, modafinil and flmodafinil are FDA-approved drugs, so they are safe to use. Both are excellent stimulants and are found to be used more by business executives, creatives, and students to enhance their productivity to get more pay, earn more, and ace the exams. With the use of these stimulants, consumers have found themselves more active throughout the day. These drugs promote restlessness; it turns ON the switch of your brain to feel attentive and enthusiastic.  

Many experts prescribe one drug over another, depending on your body conditions. That’s why one should always take these drugs as per the prescribed dose. Also, both drugs work as stimulants and have almost similar mechanisms of action, but there are still many differences between them. Therefore, only experts can prescribe which drug to use as per your body’s condition. The critical differences between modafinil and flmodafinil are

Higher Bioavailability Of Flmodafinil

Flmodafinil, also known as CRL-40,940, NLS-40, or Lauflumide, is much stronger than modafinil as it is its derivative. Flmodafinil has higher bioavailability as compared to modafinil. As seen in mice studies, flmodafinil has an increased duration of wakefulness as compared to modafinil, and the dose required to achieve the results was almost half. This proved that flmodafinil has higher bioavailability and is indeed a more potent drug. It has been found that while you might need 100-200mg of modafinil to overcome sleepiness and flmodafinil give better results with 50-75mg dose.

Some people have experienced that the effects of modafinil are potent but diminish faster, so they prefer modafinil. However, the impact of flmodafinil lasts for 6 hours, and the results of modafinil seem to linger throughout the night. So, one should always take drugs according to their schedule and body mechanics.

Genric Names Of Both Drugs

Brands and generic versions are available for both drugs. Having almost similar effects, both drugs have slightly different formulas and come under various generic names. For example, Modafinil comes under the brand name Provigil and flmodafinil, Nuvigil. Both are consumed orally with differences in their doses.

Side Effects Of Drugs

Every drug comes with side effects that vary from person to person. The common side effects of Modafinil and Flmodafinil are headache, nausea, insomnia, dizziness, and anorexia. But Modafinil is likely to be caused other side effects, such as rhinitis, backache, sinusitis, nervousness, and diarrhea. Some people who take modafinil daily have also experienced decreased appetite, but with Flmodafinil, they didn’t. Comparatively, the frequency of side effects is seen to be less in flmodafinil.

Plasma Concentration Of Flmodafinil

The plasma concentration of the drug Flmodafinil is higher than Modafinil. Studies have shown that flmodafinil has a greater half-life, so it remains longer in blood plasma than modafinil. The higher the half-life of the drug, the longer the effects will last. On contrary, the plasma concentration of modafinil cannot be made equivalent by increasing its dose.


Modafinil and flmodafinil both are CNS stimulants and completely safe to use. You can only prefer one drug over another, depending on your body’s needs. However, you can not take both stimulants together because they contain the same ingredients and can cause severe adverse effects. Higher bioavailability, plasma concentration, and effects make flmodafinil more popular among people.

It is said to be the latest drug as Modafinil is available for years, and no change in the formula has been done. You can call Flmoadinil, the latest and modified form of Modafinil with few differences. Researches conclude that if you are looking for something aggressive and potent, go for Flmodafinil; otherwise, Modafinil also gives the needed effects.

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Andrew Coria is the main partner at SNB and a dedicated Warrior in the fight for Kratom. He has served thousands of customers during his work in the industry and yet still thinks of himself as a customer as well. His work has been featured on popular kratom blogs such as Kratom Guides and Red Storm Scientific actively discussing trending botanical topics in the industry. Andrew works only with highly vetted farmers whom he trusts to make quality their #1 factor for the customer. His expertise is practiced by providing the cleanest products on the market, backed by industry-standard lab testing.


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